In Centrifugal Field-Flow Fractionation (CF3) the separation force isÂ established by a centrifugal field, which is generated by spinning theÂ complete circular channel at a high rate. The bigger and denserÂ particles are forced more in the direction of the outer wall than theÂ smaller particles. As a consequence, bigger particles are eluted laterÂ from the CF3 channel as they are located in slower streamlines in theÂ channel than the smaller particles which are located in faster streamÂ lines.
Based on the CF3 principle, the Postnova CF2000 employs a centrifugalÂ field as the driving force for separations. Particles affected by thisÂ field are separated by dynamic diffusion on the basis of both particleÂ size and density. This unique feature of the CF2000 allows theÂ separation of different particulate materials having the same particleÂ size. Separations on the CF2000 can be further optimized by usingÂ different eluents and temperature programs. As a consequence, the CF2000Â system is proving an ideal tool for the separation and characterizationÂ of complex particulate samples in areas including agriculture,Â cosmetics, nanomaterials and pharmaceutical drug delivery systems.
In contrast to traditional particle sizing techniques which work in theÂ batch mode, the CF3 technique physically separates each particleÂ fraction prior to sizing. This avoids numerous disadvantages of theseÂ batch techniques such as, low size resolution, discrimination and underÂ estimation of smaller compared to larger particles. Using Postnova CF3Â technology no special sample preparation is necessary as they can beÂ injected directly without filtration, allowing the characterization ofÂ even complex particulate materials without alteration and damage.